The paleo diet may reduce the risk of cardiovascular disease via IL-10

Interleukin-10 is a cytokine that tends to limit inflammation and also controls some aspects of our immune systems. Increasing interleukin-10 levels may be healthful.

“Chad Dolan, of the Laboratory of Integrative Psychology at the University of Houston, TX, and colleagues found that healthy adults who swapped from a Western diet to a Paleo diet experienced an increase in interleukin-10 (IL-10) levels, indicating a lower risk of heart attack and cardiovascular disease.”

Source: The Paleo diet: Could it reduce the risk of cardiovascular disease? – Medical News Today

Paleo diet is too expensive and causes diarrhea

“The Paleolithic diet has been receiving media coverage in Australia and claims to improve overall health. The diet removes grains and dairy, whilst encouraging consumption of fruits, vegetables, meat, eggs and nuts. Our aim was to compare the diet to the Australian Guide to Healthy Eating (AGHE) in terms of compliance, palatability and feasibility.”

Source: Compliance, Palatability and Feasibility of PALEOLITHIC and Australian Guide to Healthy Eating Diets in Healthy Women: A 4-Week Dietary Intervention. – PubMed – NCBI

Amy Tenderich at Healthline Explores the Paleo Diet as an Approach to Diabetes

Please click over and take a look:

“The Paleo Diet, otherwise known as the “Caveman Diet,”  is hugely popular at the moment. And lots of folks want to know how it plays with diabetes…

The DiabetesMine Team has taken a deep dive here into what this eating plan entails, and what nutrition experts and research have to say about it.”

Source: The Paleo (Caveman) Diet and Diabetes

Are Gut Bacteria and Obesity Linked?

A new meta-analysis suggests there is no link:

“Popular hypotheses suggesting actionable links between obesity and the bacterial makeup of the human digestive system are difficult to support, a new analysis concluded.

The analysis examined 10 previous studies on the topic, and raises doubts over those studies’ suggestions that a certain “signature” in the digestive systems or microbiomes of obese mammals might increase a person’s likelihood of weight gain or obesity, reported Patrick Schloss, PhD, and Marc A. Sze, PhD, both of the University of Michigan in Ann Arbor, in mBio.”

Source: Gut Bacteria and Obesity: How Strong a Link? | Medpage Today

40% of U.S. Women Now Obese; Men’s Rate Holding at 35%

That excess weight can shorten your life

That excess weight can shorten your life

Yahoo has a brief article with a few more details. For $30 you can read the original scientific report from Journal of the American Medical Association.

Obesity in this context is defined as a body mass index of 30 or higher. Calculate your BMI here.

Is it your fault if you’re obese?

Steve Parker, M.D.

PS: If you want to buck the overweight/obesity trend, check out my books.

QOTD: E.E. Blaak on Optimal Diet

Grain-based high-carb Neolithic food

Grain-based high-carb Neolithic food

Overall, energy restriction is the primary factor producing weight loss, and it is increasingly understood that distinct macronutrients may vary in energy yield and effects on satiety, also based on individuals’ phenotype and genotype. Although an overall healthy diet, either Mediterranean or a low-fat, high-complex carbohydrate diet may be effective in diabetes and cardiovascular prevention, insight is increasing that dietary prevention or treatment may require more personalized approaches to become most effective.

     —E.E. Blaak, in a review of effects of dietary carbohydrate in body weight control, glucose homeostasis and cardiovascular risk

In plain English, Blaak is saying:

  • weight loss depends on calorie restriction
  • proteins, fats, and carbs provide different amounts of energy and have different effects on hunger
  • your response to proteins, fats, and carbs depends on your genes and how you look
  • the healthiest diet for you probably isn’t the best for everyone else

Steve Parker, M.D.

Jamie Scott Reflects On His Boulder, CO, Trip

Living in the U.S. and not being an international traveler, I’m interested in how foreigners perceive the U.S.  Jamie Scott (from New Zealand) was recently in Boulder, CO, for the Ancestral Health Symposium. Parts of this trip he loved, but others, not so much:

“Let’s put this bluntly – we HATE travelling inside America.  The best way to describe it is dehumanising.  From the time you set foot on American soil, you never feel welcome. You are herded, yelled at, scolded, and glared at.  San Francisco is generally a much better entry point than LAX, but it is still terrible.

I always arrive with the intention of treating everyone doing their job like a human being, but by the time I was through immigration and heading toward the TSA screening for our connecting flight to Denver, I was seriously needing to bite my tongue.  It didn’t matter whether it was the person checking our baggage through, the person checking our passports at TSA, or the cabin crew on our flight – not a single one had the ability to acknowledge you as a human being in front of them.  Even the armed guard checking tickets on our train ride from downtown Denver to the airport left us feeling barked at and interrogated.”

Source: In Thin Air | re|evolutionary

In case you don’t know it, Boulder has little resemblance to the rest of the U.S.

Tom Naughton Eviscerates S. Andrikopoulos

Sof Andrikopoulos recently criticized the paleo diet as being unfit for folks with diabetes. Tom disagrees. For example:

“Andrikopoulos isn’t exactly a common name, yet it sounded familiar.  So I searched the blog.  Sure enough, I wrote a post about the Aussie perfesser back in February after he produced a study purporting to demonstrate that a paleo diet will makes us fat and sick.  I say purporting because the (ahem) “study” was on mice … and the “paleo” diet tripled the furry little subjects’ sugar intake, provided all their protein in the form of casein (just like yer average paleo diet, eh?) and increased their normal fat intake by 2567 percent – with much of the fat coming from canola oil.  Yup, sounds exactly like my paleo diet.”

Source: Fat Head » This Is Why So Many Australians Have Diabetes


Dementia risk increased with calcium supplements in women with cerebrovascular disease

He's not worried about adequate dietary calcium

He’s not worried about adequate dietary calcium

The paleo diet is relatively low in calcium content. So is that a reason to take a calcium supplement? Probably not. Calcium supplements are problematic. They may increase the risk of heart attacks. They may raise the odds of premature cardiac death in men. High calcium consumption increased the risk of death in Swedish women.

MedicalNewsToday has a brief report on dementia in women with cerebrovascular disease and calcium supplements:

“Calcium supplements may increase the risk of developing dementia in senior women with cerebrovascular disease, finds a study published in Neurology, the medical journal of the American Academy of Neurology.

Women who took calcium supplements were twice as likely to develop dementia.Cerebrovascular diseases are conditions caused by problems that affect the blood supply to the brain. The four most common types of cerebrovascular disease are stroke, transient ischemic attack (TIA), subarachnoid hemorrhage, and vascular dementia.”

Source: Dementia risk increased with calcium supplements in certain women – Medical News Today

The First Humans In the Americas Arrived By Boat, Not the Bering Land Bridge

An article at ArsTechnica makes the argument:

“The standard story of how humans arrived in the Americas is that they marched 1,500km across the Bering Land Bridge, a now-vanished landmass between Siberia and Northern Canada that emerged roughly 15,000 years ago in the wake of the last ice age. But for the past decade, evidence has been piling up that humans arrived in the Americas by traveling in boats along the Pacific coast. Some 14,000-year-old campsites like Oregon’s Paisley Caves have been found near rivers that meet the Pacific, suggesting that early humans came inland from the coast along these waterways. Now, a new study published in Nature provides more solid evidence the first humans to reach the Americas could not have come via the Bering Land Bridge.”

Source: Time to scrap the idea that humans arrived in the Americas by land bridge | Ars Technica