Are We Eff’d Up Due to Electric Light at Night?

No electricity

From the Journal of Pineal Research:

Key to the transition of humans from nomadic hunting-gathering groups to industrialized and highly urbanized societies was the creation of protected and artificially lit environments that extended the natural daylight hours and consolidated sleep away from nocturnal threats. These conditions isolated humans from the natural regulators of sleep and exposed them higher levels of light during the evening, which are associated with a later sleep onset. Here we investigated the extent to which this delayed timing of sleep is due to a delayed circadian system. We studied two communities of Toba/Qom Argentina, one with and the other without access to electricity. These communities have recently transitioned from a hunting-gathering subsistence to mixed subsistence systems and represent a unique model in which to study the potential effects of the access to artificial light on sleep physiology. We have previously shown that participants in the community with access to electricity had, compared to participants in the community without electricity, later sleep onsets and shorter sleep bouts. Here we show they also have a delayed dim light melatonin onset (DLMO). This difference is present during the winter but not during the spring when the influence of evening artificial light is likely less relevant. Our results support the notion that the human transition into artificially lit environments had a major impact on physiological systems that regulate sleep timing, including the phase of the master circadian clock.

Source: Access to electric light is associated with delays of the dim light melatonin onset in a traditionally hunter-gatherer Toba/Qom community – PubMed

Steve Parker, M.D.

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During Maintenance of Weight Loss, Low-Carb Eating Allows You to Eat More…Calories

Low-Carb: Spaghetti squash “spaghetti” with meaty sauce

From The Journal of Nutrition:

In this analysis of a large feeding study, we observed higher estimated energy requirement on a low- compared with high-carbohydrate diet during weight-loss maintenance. The magnitude of this effect (about 200 to 300 kcal/d, or ∼50 kcal/d for every 10% decrease in carbohydrate as a proportion of total energy) and the numerical order across groups (Low-Carb > Moderate-Carb > High-Carb) are commensurate with previously reported changes in TEE [total energy expenditure], supporting the carbohydrate-insulin model.

Source: Energy Requirement Is Higher During Weight-Loss Maintenance in Adults Consuming a Low- Compared with High-Carbohydrate Diet | The Journal of Nutrition | Oxford Academic

In other words, in order to maintain weight loss, you have to (or can) eat more calories if you’re eating low-carb versus high-carb. If your chosen calories are expensive, this could be a drawback. On the other hand, many folks who lose weight complain that they just can’t eat very much or they’ll gain the weight right back. So, if they eat low-carb style, they CAN eat more……calories. Just not more Doritos and Ding-Dongs.

Steve Parker, M.D.

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Steve Cooksey Returns to Full Carnivore Diet for Diabetes

Carnivore diet, but not raw

At Diabetes Warrior:

In this post I will be discussing my latest experiment. I am calling it “Diabetic Carnivore 2.0”. It’s 2.0 because I went ‘full-carnivore’ in 2017 for about three years, before tapering off earlier in 2020.

I’ll answer these questions in this post:

1) What is a carnivore in the context of this dietary experiment?
2) Why am I going ‘full-carnivore’ again?

*  *  *

Had we only grown lower carb, leafy green vegetables in our garden, I’d still be eating them probably … but we didn’t. We also grew higher carb vegetables and fruits like tomatoes, beets, turnips, onions and carrots.

We started out eating collards, chard and turnip green salads … all was well. Then I began easing turnips, carrots, beets, and tomatoes into our slaw. Small portions at first… but then the ‘carb creep’ happened. I would add more and more of the sugary, starchy veggies and fruits to the slaw, as well as eat more and more of them.

I only tracked my daily intake of carbs from the vegetables and fruits once. That one day, my carb totals were in the 70 gram range! Not a lot compared to ‘Standard American Diet’ but a lot compared to my typical ‘near zero carb’ meal plan.

Just like a previous high carb experiment (see this post, “Very Low Fat (and high carb) Experiment“), my body handled the sugar and starches from the vegetables pretty well at first but then the fasting blood sugars began to creep up.

Read on to see the connection to COVID-19.

In case you’re wondering, a carnivore diet is not a typical paleo diet.

Steve Parker, M.D.

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Public health for the hunter-gatherer in us

So cheesy…

From Canadian Journal of Public Health:

Abstract:

In evolutionary terms, the transformations which humans have engendered in social, ecological and built environments are increasingly out of step with their biological makeup. We briefly review the evidence on health-relevant practices and status of our Paleolithic ancestors and contrast these with current food, transportation, work and governance systems with their associated impacts on human health. As public health and planning practitioners engaged in the EcoHealth Ontario Collaborative, we argue for recognition of our hunter-gatherer nature to promote joint efforts in building sustainable and equitable community infrastructures, both built and green. Although such efforts are underway at multiple jurisdictional levels across Canada, the pace is frustratingly slow for the burden of endemic chronic diseases and global environmental change which humans face. Reminding reluctant stakeholders of the hunter-gatherers in us all could bring about deeper reflection on the urgent work in redirecting community planning.

Source: Public health for the hunter-gatherer in us all – PubMed

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If You Must Eat Grains, Minimally-Processed May Be Better for You

From Diabetes Care:

Consuming less-processed whole-grain foods over 2 weeks improved measures of glycemia in free-living adults with type 2 diabetes compared with an equivalent amount of whole-grain foods that were finely milled. Dietary advice should promote the consumption of minimally processed whole grains.

Source: Whole-Grain Processing and Glycemic Control in Type 2 Diabetes: A Randomized Crossover Trial | Diabetes Care

Steve Parker, M.D.

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Literature Review: Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors

Cavewomen didn’t have modern=make=up

From Iran and the journal Advances In Nutrition:

Abstract

There is some evidence supporting the beneficial effects of a Paleolithic Diet (PD) on cardiovascular disease risk factors. This diet advises consuming lean meat, fish, vegetables, fruits, and nuts and avoiding intake of grains, dairy products, processed foods, and added sugar and salt. This study was performed to assess the effects of a PD on cardiovascular disease risk factors including anthropometric indexes, lipid profile, blood pressure, and inflammatory markers using data from randomized controlled trials. A comprehensive search was performed in the PubMed, Scopus, ISI Web of Science, and Google Scholar databases up to August, 2018. A meta-analysis was performed using a random-effects model to estimate the pooled effect size. Meta-analysis of 8 eligible studies revealed that a PD significantly reduced body weight [weighted mean difference (WMD) = -2.17 kg; 95% CI: -3.48, -0.87 kg], waist circumference (WMD = -2.90 cm; 95% CI: -4.51, -1.28 cm), body mass index (in kg/m2) (WMD = -1.15; 95% CI: -1.68, -0.62), body fat percentage (WMD = -1.38%; 95% CI: -2.08%, -0.67%), systolic (WMD = -4.24 mm Hg; 95% CI: -7.11, -1.38 mm Hg) and diastolic (WMD = -2.95 mm Hg; 95% CI: -4.72, -1.18 mm Hg) blood pressure, and circulating concentrations of total cholesterol (WMD = -0.22 mg/dL; 95% CI: -0.42, -0.03 mg/dL), TGs (WMD = -0.23 mg/dL; 95% CI: -0.46, -0.01 mg/dL), LDL cholesterol (WMD = -0.13 mg/dL; 95% CI: -0.25, -0.01 mg/dL), and C-reactive protein (CRP) (WMD = -0.41 mg/L; 95% CI: -0.81, -0.008 mg/L) and also significantly increased HDL cholesterol (WMD = 0.05 mg/dL; 95% CI: 0.005, 0.10 mg/dL). However, sensitivity analysis revealed that the overall effects of a PD on lipid profile, blood pressure, and circulating CRP concentrations were significantly influenced by removing some studies, hence the results must be interpreted with caution. Although the present meta-analysis revealed that a PD has favorable effects on cardiovascular disease risk factors, the evidence is not conclusive and more well-designed trials are still needed.

Source: Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – PubMed

An editorial expression of concern about the article:

The Editors have been alerted by a reader with concerns about this meta-analysis. Specifically, the reader noted discrepancies in reported effect sizes and time periods, as well as confidence intervals, none of which the reader was able to reproduce. The Editors have contacted the authors, who have addressed initial concerns. However, due to the extent of the material about which concerns have been raised, the Editors need additional time to re-review this article after corrections have been made.

In the interim, this expression of concern should be taken…

Steve Parker, M.D.

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Multiple Sclerosis and the Paleo Diet

Not Dr Terry Wahls

From a recent scientific article:

Preliminary studies suggest that a modified Paleolithic diet may benefit symptoms of fatigue in progressive multiple sclerosis (MS). However, this diet restricts the consumption of eggs, dairy, and gluten-containing grains, which may increase the risk of micronutrient deficiencies. Therefore, we evaluated the nutritional safety of this diet among people with progressive MS. Three nonconsecutive 24-h dietary recalls were collected from (n = 19) progressive MS participants in the final months of a diet intervention study and analyzed using Nutrition Data System for Research (NDSR) software. Food group intake was calculated, and intake of micronutrients was evaluated and compared to individual recommendations using Nutrient Adequacy Ratios (NARs). Blood was drawn at baseline and the end of the study to evaluate biomarker changes. Mean intake of fruits and vegetables exceeded nine servings/day and most participants excluded food groups. The intake of all micronutrients from food were above 100% NAR except for vitamin D (29.6 ± 34.6%), choline (73.2 ± 27.2%), and calcium (60.3 ± 22.8%), and one participant (1/19) exceeded the Tolerable Upper Limit (UL) for zinc, one (1/19) for vitamin A, and 37% (7/19) exceeded the chronic disease risk reduction (CDRR) for sodium. When intake from supplements was included in the analysis, several individuals exceeded ULs for magnesium (5/19), zinc (2/19), sodium (7/19), and vitamins A (2/19), D (9/19), C (1/19), B6 (3/19), and niacin (10/19). Serum values of vitamins D, B12, K1, K2, and folate significantly increased compared to respective baseline values, while homocysteine and magnesium values were significantly lower at 12 months. Calcium and vitamin A serum levels did not change. This modified Paleolithic diet is associated with minimal nutritional risks. However, excessive intake from supplements may be of concern

Source: Eating Pattern and Nutritional Risks Among People With Multiple Sclerosis Following a Modified Paleolithic Diet – PubMed

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How Did Paleolithic Man Trim His Nails?

He had no modern shoe, gloves, or paring knives.

From Science ABC:

Before humans developed blades or social expectations of hygiene, how did we handle the inexorably growing nails at the ends of our fingers?

The answer to this question is quite simple… the fingernails probably took care of themselves. Fingernails are largely made up of keratin, a hardened protein that is also found in the skin and hair. While keratin is hardy and durable, it is far from unbreakable, as any woman with a chipped nail will attest. Similarly, when you clip your nails with any of the clippers explained above, there is some resistance, but they are relatively easy to snip off.

Now, think back 100,000 years, when early humans behaved as hunter-gatherers, engaging in physically demanding activities to survive. Over the course of their normal days, they may have been digging tubers out of the ground, sharpening a rudimentary spear, carrying temporary shelters or trying to start a fire. With all of this manual labor, it is believed that the fingernails would have naturally been worn down and chipped away. The daily demands of survival would have kept the fingernails from growing to unruly or unmanageable lengths. As mentioned above, we see this passive maintenance in other species as well, such as dogs that are often walked on pavement, which gradually wears down their nails, thus requiring fewer nail trimmings at the vet.If the fingernails of these early humans did break or chip, they likely solved the problem as we do today—giving them a nibble and maybe tugging off the occasional irritating hangnail. Again, we see this same behavior in other species who lick at, soften, and bite their nails when they grow too long.

The tribal elites probably didn’t to as much physical labor as the proletarians. so I imaging they and others could have used flat rocks as nail files.

The linked article covers nail trimming over the last 10,000 years, too.

Source: How did ancient people cut their nails before the nail clipper was invented?

Steve Parker, M.D.

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For Type 2 Diabetes, Gastric Bypass May Improve Cardiac and Renal Outcomes

Steve Parker MD, bariatric surgery, gastric bypass

Band Gastric Bypass Surgery

From a recent Diabetes Care article:

Our data suggest robust benefits for renal outcomes, heart failure, and CV [cardiovascular] mortality after GBP [gastric bypass] in individuals with obesity and T2DM. These results suggest that marked weight loss yields important benefits, particularly on the cardiorenal axis (including slowing progression to end-stage renal disease), whatever the baseline renal function status.

Source: Renal and Cardiovascular Outcomes After Weight Loss From Gastric Bypass Surgery in Type 2 Diabetes: Cardiorenal Risk Reductions Exceed Atherosclerotic Benefits | Diabetes Care

Because of the risk of surgery, I’d make sure first that diet modification was seriously tried and failed.

Steve Parker, M.D.

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Proposal: A Second Paleolithic Diet Score

Not too many folks eat rabbit these days

Offhand, I don’t recall the first paleo diet score proposed several years ago.

From June 2020 in Nutrition Research Reviews:

In a PubMed searched up to December 2019, 14 different PaleoDiet definitions were found. We observed some common components of the PaleoDiet among these definitions although we also found high heterogeneity in the list of specific foods that should be encouraged or banned within the PaleoDiet. Most studies suggest that the PaleoDiet may have beneficial effects in the prevention of cardiometabolic diseases (type 2 diabetes, overweight/obesity, cardiovascular diseases and hyperlipidemias) but the level of evidence is still weak because of the limited number of studies with large sample size, hard outcomes instead of surrogate outcomes and long-term follow-up. Finally, we propose a new PaleoDiet score composed of 11 food items, based on a high consumption of fruits, nuts, vegetables, fish, eggs and meats; and a minimum content of dairy products, grains and cereals, and legumes and practical absence of processed (or ultra-processed) foods or culinary ingredients.

Source: Scoping Review of Paleolithic Dietary Patterns: A Definition Proposal – PubMed

Steve Parker, M.D.

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