Category Archives: Paleo Diet

Does Diet Have ANY Effect on Health?

A couple of dietitians did an massive literature review looking for evidence that diet has an effect on major health conditions such as obesity, diabetes, and cardiovascular disease. Sounds interesting, and similar to my own obsessive review done between 1995 and 2005. Unknown if they examined the paleo diet. It bothers me that “hypertension” is misspelled in the abstract. For the researchers’ conclusions, you have to pay $27.95 USD.

“How did the paleo diet fare?”

Abstract from the Journal of the Academy of Nutrition and Dietetics:

Appropriate diet can prevent, manage, or reverse noncommunicable health conditions such as obesity, cardiovascular disease, and diabetes. Consequently, the public’s interest in diet and nutrition has fueled the multi-billion-dollar weight loss industry and elevated its standing on social media and the internet. Although many dietary approaches are popular, their universal effectiveness and risks across overall populations are not clear. The objective of this scoping review was to identify and characterize systematic reviews (SRs) examining diet or fasting (intermittent energy restriction [IER]) interventions among adults who are healthy or may have chronic disease. An in-depth literature search of six databases was conducted for SRs published between January 2010 and February 2020. A total of 22,385 SRs were retrieved, and 1,017 full-text articles were screened for eligibility. Of these, 92 SRs met inclusion criteria. Covered diets were organized into 12 categories: high/restricted carbohydrate (n = 30), Mediterranean, Nordic, and Tibetan (n = 19), restricted or modified fat (n = 17), various vegetarian diets (n = 16), glycemic index (n = 13), high protein (n = 12), IER (n = 11), meal replacements (n = 11), paleolithic (n = 8), Dietary Approaches to Stop Hypretension (DASH; n = 6), Atkins, South Beach, and Zone (n = 5), and eight other brand diets (n = 4). Intermediate outcomes, such as body weight or composition and cardiometabolic, were commonly reported. Abundant evidence was found exploring dietary approaches in the general population. However, heterogeneity of diet definitions, focus on single macronutrients, and infrequent macronutrient subanalyses were observed. Based on this scoping review, the Evidence Analysis Center prioritized the need to collate evidence related to macronutrient modification, specifically restricted carbohydrate diets.


Steve Parker, M.D.

Evidence for Ancient Beer and Porridge

Photo by LilacDragonfly on Pexels.com

Interesting article in Nature from June 2021:

On a clear day, the view from the ruins of Göbekli Tepe stretches across southern Turkey all the way to the Syrian border some 50 kilometres away. At 11,600 years old, this mountaintop archaeological site has been described as the world’s oldest temple — so ancient, in fact, that its T-shaped pillars and circular enclosures pre-date pottery in the Middle East.

The people who built these monumental structures were living just before a major transition in human history: the Neolithic revolution, when humans began farming and domesticating crops and animals. But there are no signs of domesticated grain at Göbekli Tepe, suggesting that its residents hadn’t yet made the leap to farming. The ample animal bones found in the ruins prove that the people living there were accomplished hunters, and there are signs of massive feasts. Archaeologists have suggested that mobile bands of hunter-gatherers from all across the region came together at times for huge barbecues, and that these meaty feasts led them to build the impressive stone structures.

Now that view is changing, thanks to researchers such as Laura Dietrich at the German Archaeological Institute in Berlin. Over the past four years, Dietrich has discovered that the people who built these ancient structures were fuelled by vat-fulls of porridge and stew, made from grain that the ancient residents had ground and processed on an almost industrial scale1. The clues from Göbekli Tepe reveal that ancient humans relied on grains much earlier than was previously thought — even before there is evidence that these plants were domesticated. And Dietrich’s work is part of a growing movement to take a closer look at the role that grains and other starches had in the diet of people in the past.

The researchers are using a wide range of techniques — from examining microscopic marks on ancient tools to analysing DNA residues inside pots. Some investigators are even experimentally recreating 12,000-year-old meals using methods from that time. Looking even further back, evidence suggests that some people ate starchy plants more than 100,000 years ago. Taken together, these discoveries shred the long-standing idea that early people subsisted mainly on meat — a view that has fuelled support for the palaeo [sic] diet, popular in the United States and elsewhere, which recommends avoiding grains and other starches.

Steve Parker, M.D.

Paleo Diet: More Carbohydrates Than We Think?

Photo by Andru00e9 Cook on Pexels.com

I haven’t read the full article in Journal of Human Evolution because I don’t want to part with $20 it costs. Here’s the abstract:

Evidence for plants rarely survives on Paleolithic sites, while animal bones and biomolecular analyses suggest animal produce was important to hominin populations, leading to the perspective that Neanderthals had a very-high-protein diet. But although individual and short-term survival is possible on a relatively low-carbohydrate diet, populations are unlikely to have thrived and reproduced without plants and the carbohydrates they provide. Today, nutritional guidelines recommend that around half the diet should be carbohydrate, while low intake is considered to compromise physical performance and successful reproduction. This is likely to have been the same for Paleolithic populations, highlighting an anomaly in that the basic physiological recommendations do not match the extensive archaeological evidence. Neanderthals had large, energy-expensive brains and led physically active lifestyles, suggesting that for optimal health they would have required high amounts of carbohydrates. To address this anomaly, we begin by outlining the essential role of carbohydrates in the human reproduction cycle and the brain and the effects on physical performance. We then evaluate the evidence for resource availability and the archaeological evidence for Neanderthal diet and investigate three ways that the anomaly between the archaeological evidence and the hypothetical dietary requirements might be explained. First, Neanderthals may have had an as yet unidentified genetic adaptation to an alternative physiological method to spare blood glucose and glycogen reserves for essential purposes. Second, they may have existed on a less-than-optimum diet and survived rather than thrived. Third, the methods used in dietary reconstruction could mask a complex combination of dietary plant and animal proportions. We end by proposing that analyses of Paleolithic diet and subsistence strategies need to be grounded in the minimum recommendations throughout the life course and that this provides a context for interpretation of the archaeological evidence from the behavioral and environmental perspectives.

Is the Paleo Diet the Easiest to Stick With?

I’ve never eaten rabbit, but would try it. A patient in Florida cooked squirrel for me. Tastes like chicken, as I recall.

An article at Public Health Nutrition suggests that, yes, the paleo diet is one of the last to be abandoned. I’m not paying the $35 for access to the full article, so I don’t know which diets were considered. I assume all the popular ones.

Abstract

Objective: To use Internet search data to compare duration of compliance for various diets.

Design: Using a passive surveillance digital epidemiological approach, we estimated the average duration of diet compliance by examining monthly Internet searches for recipes related to popular diets. We fit a mathematical model to these data to estimate the time spent on a diet by new January dieters (NJD) and to estimate the percentage of dieters dropping out during the American winter holiday season between Thanksgiving and the end of December.

Setting: Internet searches in the USA for recipes related to popular diets over a 15-year period from 2004 to 2019.

Participants: Individuals in the USA performing Internet searches for recipes related to popular diets.

Results: All diets exhibited significant seasonality in recipe-related Internet searches, with sharp spikes every January followed by a decline in the number of searches and a further decline in the winter holiday season. The Paleo diet had the longest average compliance times among “new January dieters” (5.32 ± 0.68 weeks) and the lowest dropout during the winter holiday season (only 14 ± 3 % dropping out in December). The South Beach diet had the shortest compliance time among NJD (3.12 ± 0.64 weeks) and the highest dropout during the holiday season (33 ± 7 % dropping out in December).

Conclusions: The current study is the first of its kind to use passive surveillance data to compare the duration of adherence with different diets and underscores the potential usefulness of digital epidemiological approaches to understanding health behaviours.

Steve Parker, M.D.

Introducing the “Paleo Ratio” as an Assessment of Paleo Diet Compliance

The study at hand did not find an improvement in hemoglobin A1c in type 2 diabete after 12 weeks of intervention. I’m surprised. I haven’t read the whole report yet.

Abstract

This study is a secondary analysis of a randomized controlled trial using Paleolithic diet and exercise in individuals with type 2 diabetes. We hypothesized that increased adherence to the Paleolithic diet was associated with greater effects on blood pressure, blood lipids and HbA1c independent of weight loss. Participants were asked to follow a Paleolithic diet for 12 weeks and were randomized to supervised exercise or general exercise recommendations. Four-day food records were analyzed, and food items characterized as “Paleolithic” or “not Paleolithic”. Foods considered Paleolithic were lean meat, poultry, fish, seafood, fruits, nuts, berries, seeds, vegetables, and water to drink; “not Paleolithic” were legumes, cereals, sugar, salt, processed foods, and dairy products. A Paleo ratio was calculated by dividing the Paleolithic calorie intake by total calorie intake. A multiple regression model predicted the outcome at 12 weeks using the Paleo ratio, group affiliation, and outcome at baseline as predictors.

The Paleo ratio increased from 28% at baseline to 94% after the intervention. A higher Paleo ratio was associated with lower fat mass, BMI, waist circumference, systolic blood pressure, and serum triglycerides at 12 weeks, but not with lower HbA1c levels. The Paleo ratio predicted triglyceride levels independent of weight loss (p = 0.046). Moreover, an increased monounsaturated/saturated fatty acids ratio and an increased polyunsaturated/saturated fatty acids ratio was associated with lower triglyceride levels independent of weight loss. (p = 0.017 and p = 0.019 respectively).

We conclude that a higher degree of adherence to the Paleolithic diet recommendations improved fat quality and was associated with improved triglyceride levels independent of weight loss among individuals with type 2 diabetes.

Source: Using a Paleo Ratio to Assess Adherence to Paleolithic Dietary Recommendations in a Randomized Controlled Trial of Individuals with Type 2 Diabetes – PubMed

Steve Parker, M.D.

Meta-Analysis: Paleolithic diet effects on glucose metabolism and lipid profile among patients with metabolic disorders

See modern man walking off that cliff?

From mostly Iran-based researchers, published in Critical Reviews in Food Science and Nutrition:

Abstract

Objective:

Several randomized clinical trials (RCTs) have investigated the effects of the Paleolithic diet (PD) in adult patients suffering from metabolic disorders. However, the results of these RCTs are conflicting. Therefore, we conducted a systematic review and meta-analysis to assess the effects of the PD in patients with metabolic disorders.

Methods:

We searched the PubMed/Medline, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases up to June, 2020. The data were pooled using a random-effects model. From the eligible publications, 10 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. The heterogeneity was determined using the I2 statistics and the Cochrane Q test.

Results:

The pooled results from the random-effects model showed a significant reduction of the homeostatic model assessment of insulin resistance (HOMA-IR) (weighted mean difference, WMD: -0.39, 95% CI: -0.70, -0.08), fasting insulin (WMD: -12.17 μU/mL, 95% CI: -24.26, -0.08), total cholesterol (WMD: -0.32 mmol/l, 95% CI: -0.49, -0.15), triglycerides (WMD: -0.29 mmol/L, 95% CI: -0.42, -0.16), low-density lipoprotein cholesterol (WMD: -0.35 mmol/L, 95% CI: -0.67, -0.03), blood pressure (BP)(WMD – 5.89 mmHg; 95% CI – 9.973 to – 1.86 for the systolic BP and WMD – 4.01 mmHg; 95% CI – 6.21 to – 1.80 for the diastolic BP values) and C-reactive protein (CRP) levels (WMD: -0.84, mg/L, 95% CI: -1.62, -0.06) in the PD group versus control group.

Conclusions:

Our findings provide better insights into the effect of the PD on the modulation of the glucose and lipid metabolism factors in patients with metabolic disorders, providing comprehensive information for the development of future RCTs with a high quality design.

Source: The effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials – PubMed

Proposal: A Second Paleolithic Diet Score

Not too many folks eat rabbit these days

Offhand, I don’t recall the first paleo diet score proposed several years ago.

From June 2020 in Nutrition Research Reviews:

In a PubMed searched up to December 2019, 14 different PaleoDiet definitions were found. We observed some common components of the PaleoDiet among these definitions although we also found high heterogeneity in the list of specific foods that should be encouraged or banned within the PaleoDiet. Most studies suggest that the PaleoDiet may have beneficial effects in the prevention of cardiometabolic diseases (type 2 diabetes, overweight/obesity, cardiovascular diseases and hyperlipidemias) but the level of evidence is still weak because of the limited number of studies with large sample size, hard outcomes instead of surrogate outcomes and long-term follow-up. Finally, we propose a new PaleoDiet score composed of 11 food items, based on a high consumption of fruits, nuts, vegetables, fish, eggs and meats; and a minimum content of dairy products, grains and cereals, and legumes and practical absence of processed (or ultra-processed) foods or culinary ingredients.

Source: Scoping Review of Paleolithic Dietary Patterns: A Definition Proposal – PubMed

Steve Parker, M.D.

Click pic to purchase book at Amazon.com. E-book versions available at Smashwords.com.

Nurse Practitioners May Advocate for Paleo Diet

The Nurse Practitioner has an article indicating that the paleo diet may prevent or treat prediabetes and diabetes:

Lifestyle changes that include adopting a healthy diet, such as the paleo diet, can help prevent prediabetes and T2DM [type 2 diabetes]. This article explores the potential benefits of replacing low-calorie diets with the paleo diet. As primary care providers, NPs [nurse practitioners] are positioned to help inform patients, particularly those with prediabetes and T2DM, about healthy lifestyle choices and provide them with resources to achieve weight loss success.

Source: Combating insulin resistance with the paleo diet : The Nurse Practitioner

I confess I haven’t read the entire article, just the abstract.

Steve Parker, M.D.

Click pic to purchase book at Amazon.com. E-book versions available at Smashwords.com.

Soybean Oil Not Healthy for Humans?

Soybean oil seems to be a real problem for male mice. We need more research in humans before outlawing it as dangerous toxin. If you’re eating the Standard American Diet, you’ll find it hard if not impossible to avoid. Of course, paleo diets should be naturally low in soybean oil.

From EurekAlert:

New UC Riverside research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer’s disease, anxiety, and depression.

Used for fast food frying, added to packaged foods, and fed to livestock, soybean oil is by far the most widely produced and consumed edible oil in the U.S., according to the U.S. Department of Agriculture. In all likelihood, it is not healthy for humans.

Source: America’s most widely consumed oil causes genetic changes in the brain | EurekAlert! Science News

Steve Parker, M.D.

Click pic to purchase book at Amazon.com. E-book versions available at Smashwords.com.

 

 

Does Calcium Consumption Help Prevent Brittle Bones in Older Women?

Waste of money and effort?

Due to a lack of milk products, paleo diets may not meet the Recommended Daily Intake of calcium. Your blood must have a certain amount of calcium, and if that level is too low, your bones donate calcium to the bloodstream.

Many physicians worry that inadequate calcium consumption causes or contributes to thin, brittle, easily breakable bones in postmenopausal women. A recent study suggests that calcium intake doesn’t matter.

Abstract

CONTEXT:

Calcium intakes are commonly lower than the recommended levels, and increasing calcium intake is often recommended for bone health.

OBJECTIVE:To determine the relationship between dietary calcium intake and rate of bone loss in older postmenopausal women.

PARTICIPANTS:

Analysis of observational data collected from a randomized controlled trial. Participants were osteopenic (hip T-scores between -1.0 and -2.5) women, aged >65 years, not receiving therapy for osteoporosis nor taking calcium supplements. Women from the total cohort (n = 1994) contributed data to the analysis of calcium intake and bone mineral density (BMD) at baseline, and women from the placebo group (n = 698) contributed data to the analysis of calcium intake and change in BMD. BMD and bone mineral content (BMC) of the spine, total hip, femoral neck, and total body were measured three times over 6 years.

RESULTS:

Mean calcium intake was 886 mg/day. Baseline BMDs were not related to quintile of calcium intake at any site, before or after adjustment for baseline age, height, weight, physical activity, alcohol intake, smoking status, and past hormone replacement use. There was no relationship between bone loss and quintile of calcium intake at any site, with or without adjustment for covariables. Total body bone balance (i.e., change in BMC) was unrelated to an individuals’ calcium intake (P = 0.99).

CONCLUSIONS:

Postmenopausal bone loss is unrelated to dietary calcium intake. This suggests that strategies to increase calcium intake are unlikely to impact the prevalence of and morbidity from postmenopausal osteoporosis.

Source: Dietary Calcium Intake and Bone Loss Over 6 Years in Osteopenic Postmenopausal Women. – PubMed – NCBI

Steve Parker, M.D.

PS: Elderly men get osteoporosis, too. But when the Emergency Department calls me to admit an older patient with a hip fracture, it’s a woman 9 out of 10 times.

Click pic to purchase book at Amazon.com