Do SGLT2 Inhibitors Increase the Risk of Amputations in Diabetics?

Good question. But we don’t know the answer yet.

European authorities and even the U.S. Food and Drug Administration are looking into the possible connection. Stay tuned. Visit The Low Carb Diabetic site (link below) for more details.

“The European Medicines Agency (EMA)’s Pharmacovigilance Risk Assessment Committee (PRAC) has extended the scope of its investigation into the possible link between the sodium glucose cotransporter 2 (SGLT2) inhibitor canagliflozin (Invokana, Vokanamet, Janssen) and amputations to include other drugs of the same class.

Now, the PRAC’s review will include the other SGLT2 inhibitor medicines dapagliflozin (Farxiga, Xigduo XR, AstraZeneca), and empagliflozin (Jardiance, Boehringer Ingelheim), based on the determination that the potential risk may be relevant for them as well.”

Source: The Low Carb Diabetic: EMA Extends Amputation Investigation to All SGLT2 Inhibitors

Steve Parker, M.D.

PS: SGLT2 inhibitors are the drugs that reduce blood glucose by shunting it into your urine. Makes more sense to me instead to reduce your blood sugar by eating fewer carbohydrates, the primary source of blood sugar in most folks.

Update May 17, 2017: On May 16, 2017, the U.S. Food and Drug Administration ruled that canagliflozin doubles the risk of foot and leg amputations, compared to placebo.


One response to “Do SGLT2 Inhibitors Increase the Risk of Amputations in Diabetics?

  1. It’s the age old scam. Hey people you don’t have to do any work! No diet! No exercise! No monitoring you carbs! Just take this tablet and you’ll never have to worry about diabetes again!

    Except you might have a higher risk of having your leg chopped off.

    As long as there are suckers out there there’ll be pharmaceuticals to takd advantage. Not that I’m against taking tablets – I’m against the belief that that’s all you need to do.

    The number of people I know that are on Met and think because of the low BGs (allegedly I’m only going by what they tell me) that they get that they just can happily go on munching toast and other high carbs. Apparently the spectre that about 30% of Met takers face devastating Vit B12 deficiency is something they don’t want to think about or are just ignorant of.