Category Archives: Evolution

Is Our Gene Pool Hopelessly Contaminated?

Counter-Currents published a review of William S. Blau’s recent book, Our Genetic Future: The Unintended Consequences of Overcoming Natural Selection. This thought-provoking and controversial book may explain why lifespans are decreasing in the U.S, cancers are becoming more frequent in younger people, and even the burgeoning “enshitification” of modern life. If you are intelligent and have an open mind, it’s worth checking out the review by Lipton Matthews. (You may be able to figure out a way to read it w/o subscribing.)

This issue reminds me of the “environmental-genetic mismatch” that many paleo diet pioneers pointed out. For example, we are not genetically programmed to eat ultrap-rocessed foods and live in close contact with thousands of other humans. Hence, we have epidemics of modern civilization, like anxiety, depression, diabetes, and hypertension.

A sample of Blau’s review:

Contemporary developed societies no longer face intense selective pressure from infectious disease. The selective advantage of immune gene variants that defended against lethal infections has vanished while autoimmune risks remain. The incidence of autoinflammatory and autoimmune disorders has increased markedly, affecting seven to nine percent of the population worldwide and ranking among leading causes of death for young and middle-aged women, with rates increasing ten to twenty percent annually over the past thirty years.

Perhaps most alarming is the documented increase in chronic disease burden across developed societies. Nearly half of American adults suffer from at least one chronic condition. Metabolic disorders including obesity, type 2 diabetes, hypertension, and fatty liver disease have increased dramatically. Early onset cancers affecting people younger than fifty are rising across multiple cancer types.

Blau cites research using the Biological State Index correlating reduced selection pressure with increased disease rates across nations. Countries with least opportunity for natural selection show dramatically higher incidences of cancers, dementia, and type 1 diabetes compared to nations where mortality remains higher. For cancers known to be strongly genetically based, incidence rates in the ten countries with least opportunity for mortality selection exceed rates in the ten countries with greatest opportunity by a factor of 5.7. These associations persist even after controlling for factors like gross domestic product, life expectancy, and lifestyle factors.

Blau’s book forces readers to confront truths that contemporary culture finds deeply unsettling. We prefer narratives of inexorable progress where science and technology ultimately solve whatever problems they create. The notion that our greatest medical triumphs may have initiated genetic degradation that will burden descendants for centuries contradicts every comforting story we tell ourselves about human advancement.


—–Steve Parker, M.D.

Sedentary Behavior Makes Sense

Sedentary lifestyle NOT an option here

I had lots of evolution indoctrination during study for my zoology degree. It helps me understand the following.

From BioEssays:

Most people are aware of the health benefits of being physically active. The question arises then why people so easily fall into sedentary habits. The idea developed here is that sedentary behavior is part of a suite of behaviors to reduce levels of physical activity that were strongly selected in the evolutionary past, likely because high levels of physical activity had direct negative consequences for survival. However, hunter-gatherer populations could not reduce activity indefinitely because of the need to be active to hunt for, and gather food. Hence they never experienced low levels of activity that are damaging to health, and no corresponding mechanism avoiding low activity evolved. Consequently, gene variants promoting efficiency of activity and increased sedentariness were never selected against. Modern society facilitates reduced activity by providing many options to become less active and divorcing food intake from the need to be active. Choosing the less active option is hard wired in the genes; this explains why being sedentary is so common, and why reversing it is so difficult.

Source: An Evolutionary Perspective on Sedentary Behavior. – PubMed – NCBI

Steve Parker, M.D.

Click pic to purchase book at Amazon.com. E-book versions available at Smashwords.com.

Butchered Bones Found in Canada Indicate Humans Came to North America 24,000 Years Ago

Fresh off the Bering Strait from Siberia?

Fresh off the Bering Strait from Siberia?

From Ancient Origins:

“Archaeologists have found a set of butchered bones dating back 24,000 years in Bluefish Caves, Yukon, Canada, which are the oldest signs of human habitation ever discovered in North America. Until recently, it was believed that the culture that represented the continent’s first inhabitants was the Clovis culture. However, the discovery of the butchered bones challenges that theory, providing evidence that human occupation preceded the arrival of the Clovis people by as much as 10,000 years.

For decades, it has been believed that the first Americans crossed the Bering Strait from Siberia about 14,000 years ago and quickly colonized North America.”

Source: 24,000-Year-Old Butchered Bones Found in Canada Change Known History of North America | Ancient Origins

The First Humans In the Americas Arrived By Boat, Not the Bering Land Bridge

An article at ArsTechnica makes the argument:

“The standard story of how humans arrived in the Americas is that they marched 1,500km across the Bering Land Bridge, a now-vanished landmass between Siberia and Northern Canada that emerged roughly 15,000 years ago in the wake of the last ice age. But for the past decade, evidence has been piling up that humans arrived in the Americas by traveling in boats along the Pacific coast. Some 14,000-year-old campsites like Oregon’s Paisley Caves have been found near rivers that meet the Pacific, suggesting that early humans came inland from the coast along these waterways. Now, a new study published in Nature provides more solid evidence the first humans to reach the Americas could not have come via the Bering Land Bridge.”

Source: Time to scrap the idea that humans arrived in the Americas by land bridge | Ars Technica

Fire and Human Evolution

Richard Wrangham figures our hominin ancestors tamed fire and started cooking with it 1.8 million years ago. Other authorities date our mastery of fire from 12,000 to 400,000 years ago.

From the New York Times:

“When early humans discovered how to build fires, life became much easier in many regards. They huddled around fire for warmth, light and protection. They used it to cook, which afforded them more calories than eating raw foods that were hard to chew and digest. They could socialize into the night, which possibly gave rise to storytelling and other cultural traditions.

But there were downsides, too. Occasionally, the smoke burned their eyes and seared their lungs. Their food was likely coated with char, which might have increased their risk for certain cancers. With everyone congregated in one place, diseases could have been transmitted more easily.”

Source: Smoke, Fire and Human Evolution – The New York Times

John Hawks Says Humans Haven’t Stopped Evolving 

Writing at TheScientist:

“Skin color is a classic example. One of the largest and most obvious physiological differences between populations, skin color is influenced by more than two dozen genes in a pathway that produces the pigment melanin and regulates the amount of this pigment in different tissues. Changes to these genes interrupt the generation of the dark pigment eumelanin, leaving skin with larger amounts of the reddish pigment pheomelanin, leading to various skin tones and patterns of coloration, such as freckles. Despite its complex genetics, skin color shows consistent patterns of evolution across the globe. People whose ancestors lived in the tropics tend to be dark-skinned, while those who lived further north and south tend to be lighter. One of the revelations of the last 15 years is just how recent this pattern really is. According to analyses of ancient DNA, people who lived in northern Europe only 10,000 years ago would not have had the extremely light skin of today’s people in that region.”

Source: Humans Never Stopped Evolving | The Scientist Magazine®

Hawks also discusses lactase persistence, eye color, blood types, and malaria resistance.

16,700-Year-Old Tools Found in Texas Change Known History of North America

“Archaeologists in Texas have found a set of 16,700-year-old tools which are among the oldest discovered in the West. Until now, it was believed that the culture that represented the continent’s first inhabitants was the Clovis culture. However, the discovery of the ancient tools now challenges that theory, providing evidence that human occupation precedes the arrival of the Clovis people by thousands of years.”

Source: 16,700-Year-Old Tools Found in Texas Change Known History of North America | Ancient Origins

When I first read this, I thought it outdated my Paleobetic Diet book. But no. On page 33 I wrote, “Northeast Asians moved into North America (Alaska) 12 to 30,000 years ago.”

Paleobetic Diet-FrontCover_300dpi_RGB_5.5x8.5

Óscar Picazo Compiled a List of Scientific Articles on the Paleolithic Diet

Not Oscar Picazo

Not Oscar Picazo

Click the link below to see the articles, which are in English. Óscar’s introduction:

“Hace ya más de un año, compartí aquí la lista actualizada de estudios hasta la fecha, en relación a la paleodieta, dieta evolutiva, o como se le quiera llamar.El último año ha sido bastante activo en este sentido, con varios trabajos publicados, varios ensayos clínicos, y un meta-análisis.A continuación la lista actualizada. Si falta alguno, por favor indícamelo y lo incluyo.Y solo por recordarlo… mi opinión sobre el tema.”

Source: Paleodieta: Bibliografía actualizada | Óscar Picazo

Thanks, Oscar!

Almost Half of California Adults Have Prediabetes

The actual figure is 46%, according to researchers at UCLA. The LA Times has the story.

“Our genes and our environment are kind of on a collision course,” said Dr. Francine Kaufman, the former head of the American Diabetes Assn., who was not involved with the research. “It’s not stopping.”

The problem with prediabetes is that it often evolves into full-blown diabetes. It’s also associated with increased risk for cardiovascular disease such as heart attack and stroke. The Times article says “up to 70% of those with prediabetes develop diabetes in their lifetime.” I’d never heard that vague number before; I say vague because “up to 70%” could be anything between zero and 70. It’s more accurate to note that one in four people with prediabetes develops type 2 diabetes over the course of three to five years.

She has the genes of a cave woman

She has the genes of a cave woman

Prediabetes is defined as:

  1. fasting blood sugar between 100 and 125 mg/dl (5.56–6.94 mmol/l), or
  2. blood sugar level 140–199 mg/dl (7.78–11.06 mmol/l) two hours after drinking 75 grams of glucose

How To Prevent Progression of Prediabetes Into Diabetes

  • If you’re overweight or obese, lose excess fat weight. How much should you lose? Aim for at least 5% of body weight and see if that cures your prediabetes. For instance, if you weigh 200 lb (91 kg), lose 10 lb (4.5 kg).
  • If you’re sedentary, start exercising regularly.
  • Cut back on your consumption of sugar-sweetened beverages, other sugar sources, and other refined carbohydrates like wheat flour.

Steve Parker, M.D.

Paleobetic Diet-FrontCover_300dpi_RGB_5.5x8.5

 

If You’re Interested In Human Evolution, You Need to Know About the Denisovans

So here’s a 10-minute video from Pique. Denisovans are a hominin group, some remains of whom were discovered in the 1970s in or near Russia. Modern native Tibetans share at least one gene with the Denisovans, a gene that helps them tolerate hypoxia (low tissue levels of oxygen).