Evidence for Ancient Beer and Porridge

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Interesting article in Nature from June 2021:

On a clear day, the view from the ruins of Göbekli Tepe stretches across southern Turkey all the way to the Syrian border some 50 kilometres away. At 11,600 years old, this mountaintop archaeological site has been described as the world’s oldest temple — so ancient, in fact, that its T-shaped pillars and circular enclosures pre-date pottery in the Middle East.

The people who built these monumental structures were living just before a major transition in human history: the Neolithic revolution, when humans began farming and domesticating crops and animals. But there are no signs of domesticated grain at Göbekli Tepe, suggesting that its residents hadn’t yet made the leap to farming. The ample animal bones found in the ruins prove that the people living there were accomplished hunters, and there are signs of massive feasts. Archaeologists have suggested that mobile bands of hunter-gatherers from all across the region came together at times for huge barbecues, and that these meaty feasts led them to build the impressive stone structures.

Now that view is changing, thanks to researchers such as Laura Dietrich at the German Archaeological Institute in Berlin. Over the past four years, Dietrich has discovered that the people who built these ancient structures were fuelled by vat-fulls of porridge and stew, made from grain that the ancient residents had ground and processed on an almost industrial scale1. The clues from Göbekli Tepe reveal that ancient humans relied on grains much earlier than was previously thought — even before there is evidence that these plants were domesticated. And Dietrich’s work is part of a growing movement to take a closer look at the role that grains and other starches had in the diet of people in the past.

The researchers are using a wide range of techniques — from examining microscopic marks on ancient tools to analysing DNA residues inside pots. Some investigators are even experimentally recreating 12,000-year-old meals using methods from that time. Looking even further back, evidence suggests that some people ate starchy plants more than 100,000 years ago. Taken together, these discoveries shred the long-standing idea that early people subsisted mainly on meat — a view that has fuelled support for the palaeo [sic] diet, popular in the United States and elsewhere, which recommends avoiding grains and other starches.

Steve Parker, M.D.

Paleo Diet Linked to Cardiovascular Benefits

A score appraising Paleolithic diet and the risk of cardiovascular disease in a Mediterranean prospective cohort

Abstract

Purpose: To assess the association between a score appraising adherence to the PaleoDiet and the risk of cardiovascular disease (CVD) in a Mediterranean cohort.

Methods: We included 18,210 participants from the Seguimiento Universidad de Navarra (SUN) cohort study. The PaleoDiet score comprised six food groups promoted within this diet (fruit, nuts, vegetables, eggs, meat and fish) and five food groups whose consumption is discouraged (cereals and grains, dairy products, legumes, culinary ingredients, and processed/ultra-processed foods). CVD was defined as acute myocardial infarction with or without ST elevation, non-fatal stroke and cardiovascular death. Cox proportional hazards models adjusted for potential confounders were fitted to assess the association between the PaleoDiet score and CVD risk, and the PaleoDiet and MedDiet indices to explore differences between both diets.

Results: During 12.2 years of follow-up, 165 incident CVD cases were confirmed. A significant inverse association was found between the PaleoDiet score and CVD (HR Q5 vs. Q1: 0.45, 95% CI 0.27-0.76, P for trend = 0.007). A weaker association that became non-significant was observed when the item for low consumption of ultra-processed foods was removed from the score. Joint analysis of PaleoDiet and MedDiet Trichopoulou scores suggested that the inverse association between PaleoDiet and CVD was mainly present when adherence to the MedDiet was also high (HR for high adherence vs low adherence to both diet scores: 0.22, 95% CI 0.08-0.64).

Conclusions: Our findings suggest that the PaleoDiet may have cardiovascular benefits in participants from a Mediterranean country. Avoidance of ultra-processed foods seems to play a key role in this inverse association.

Link to European Journal of Nutrition article.

I was glad to see some new names among the researchers.

Steve Parker, M.D.

PS: If you’ve abandoned your New Years’ diet resolution, consider the Paleobetic Diet!

Paleo Diet: More Carbohydrates Than We Think?

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I haven’t read the full article in Journal of Human Evolution because I don’t want to part with $20 it costs. Here’s the abstract:

Evidence for plants rarely survives on Paleolithic sites, while animal bones and biomolecular analyses suggest animal produce was important to hominin populations, leading to the perspective that Neanderthals had a very-high-protein diet. But although individual and short-term survival is possible on a relatively low-carbohydrate diet, populations are unlikely to have thrived and reproduced without plants and the carbohydrates they provide. Today, nutritional guidelines recommend that around half the diet should be carbohydrate, while low intake is considered to compromise physical performance and successful reproduction. This is likely to have been the same for Paleolithic populations, highlighting an anomaly in that the basic physiological recommendations do not match the extensive archaeological evidence. Neanderthals had large, energy-expensive brains and led physically active lifestyles, suggesting that for optimal health they would have required high amounts of carbohydrates. To address this anomaly, we begin by outlining the essential role of carbohydrates in the human reproduction cycle and the brain and the effects on physical performance. We then evaluate the evidence for resource availability and the archaeological evidence for Neanderthal diet and investigate three ways that the anomaly between the archaeological evidence and the hypothetical dietary requirements might be explained. First, Neanderthals may have had an as yet unidentified genetic adaptation to an alternative physiological method to spare blood glucose and glycogen reserves for essential purposes. Second, they may have existed on a less-than-optimum diet and survived rather than thrived. Third, the methods used in dietary reconstruction could mask a complex combination of dietary plant and animal proportions. We end by proposing that analyses of Paleolithic diet and subsistence strategies need to be grounded in the minimum recommendations throughout the life course and that this provides a context for interpretation of the archaeological evidence from the behavioral and environmental perspectives.

Easy Ways to Prevent COVID-19

Artist’s renditions of coronavirus

Oral preventatives during disease surges:

  • Vitamin D (cholecalciferol) 1,000-2,000 IU/day. (Gruff Davies and Linda Benskin recommend, in general, 4,000 IU daily, perhaps year-round, or whatever combination of food, supplementation, and sunlight gets your blood level of 25-hydroxy vitamin D to to 50 ng/mL.)
  • Aspirin 81-325 mg/day
  • Vitamin C 500 mg/day
  • Elemental zinc 10-50 mg/day
  • Melatonin 1.5-6 mg/day at night or bedtime

The doses vary, depending on body weight, age, tolerance to the drug. Generally, the higher doses are for younger and heavier folks. If one gets plentiful sunlight exposure, the oral vitamin D may not be needed.

Other strategies during disease surges (or always?):

  • Regular exercise
  • Lose excess weight, especially if obese (BMI over 30)
  • Maintain normal blood sugars (if diabetic, keep HgbA1c under 6.5%)
  • Avoid close, prolonged contact with coughing and sneezing people, especially in enclosed spaces
  • Frequent hand-washing if exposed to public doorknobs, elevator buttons, or other potentially contaminated surfaces, or if around sick (coughing and/or sneezing) people
  • Avoid sick people who are coughing and sneezing
  • Eat healthful food

Alternatively, from Dr Robert Malone on his Dec 31, 2021 substack:

“So, yes back to my thoughts on Omicron – please keep taking that vitamin D3 and get your levels tested, if you haven’t already.  Use a formulation that combines the D3 with Vitamins A and K. Please keep up with the zinc, vitamin C and magnesium.  Work on weight control, glycemic control and please exercise!  All are important.”

Did you notice I haven’t mentioned masks? I’m not a big believer. Do I wear an N-95 mask when I’m seeing a COVID-19 patient at the hospital? You bet. And the mask was fit-tested. Is that testing available to the general public? Not that I’m aware.

Do I have great data to support all these strategies? No, but some. Are they recommended by the CDC or NIH (Nat’l Institutes of Health)? I don’t know or care. I’ve lost faith in them. I’m afraid they’ve been bought and paid for by Big Pharma (and others?).

I don’t know about your personal health and medical history. I’m not your doctor. If you’re considering any of these recommendations, consult your personal physician before implementation.

The patient is wise to look away. If you watch the needle go in, it’ll hurt more.

I was motivated to write this post by the failures and risks of the rushed vaccines. Vaccination might be helpful if you are sickly, over 65, or have underlying conditions such as diabetes, active cancer, a poor immune system, obesity (especially BMI over 35), or some other co-morbidities. I see both very healthy, vigorous 65-year-olds, and sickly 65-year-olds. Which one are you? If you’re over 80, you may have nothing to lose by vaccinating. Average U.S. life expectancy is 79 years, less for men, longer for women.

Steve Parker, M.D.

Does the Paleo Diet Affect Cardiometabolic Risk Factors in Postmenopausal Women?

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You won’t find the answer in the journal article at hand. Probably nobody knows for sure. If you have insomnia, reading the full article (free!) may be cure you temporarily.

Whole-diet interventions and cardiovascular risk factors in postmenopausal women: A systematic review of controlled clinical trials

Abstract

Objectives: Menopause is accompanied by many metabolic changes, increasing the risk of cardiometabolic diseases. The impact of diet, as a modifiable lifestyle factor, on cardiovascular health in general populations has been well established. The purpose of this systematic review is to summarize the evidence on the effects of whole diet on lipid profile, glycemic indices, and blood pressure in postmenopausal women.

Methods: Embase, Medline, Cochrane Central Register of Controlled Trials, and Google Scholar were searched from inception to February 2021. We included controlled clinical trials in postmenopausal women that assessed the effect of a whole-diet intervention on lipid profile, glycemic indices, and/or blood pressure. The risk of bias in individual studies was assessed using RoB 2 and ROBINS-I tools.

Summary of evidence: Among 2,134 references, 21 trials met all eligibility criteria. Overall, results were heterogenuous and inconsistent. Compared to control diets, some studies showed that participants experienced improvements in total cholesterol (TC), low-density lipoprotein cholesterol (LDL), systolic blood pressure (SBP), fasting blood sugar (FBS), and apolipoprotein A (Apo-A) after following fat-modified diets, but some adverse effects on triglycerides (TG), very low-density lipoprotein cholesterol (VLDL), lipoprotein(a) (Lp(a)), and high-density lipoprotein cholesterol (HDL) concentrations were also observed. A limited number of trials found some effects of the Paleolithic, weight-loss, plant-based, or energy-restricted diets, or of following American Heart Association recommendations on TG, TC, HDL, insulin, FBS, or insulin resistance.

Conclusion: Current evidence suggests that diet may affect levels of some lipid profile markers, glycemic indices, and blood pressure among postmenopausal women. However, due to the large heterogeneity in intervention diets, comparison groups, intervention durations, and population characteristics, findings are inconclusive. Further well-designed clinical trials are needed on dietary interventions to reduce cardiovascular risk in postmenopausal women.


Steve Parker, M.D.

Other Than Vaccination, How Can You Prevent COVID-19?

Masking may be worthless. At least this is a medical-grade mask.

Oral preventatives during disease surges:

  • Vitamin D (cholecalciferol)1,000-2,000 IU/day (Gruff Davies and Linda Benskin recommend, in general, 4,000 IU daily, perhaps year-round, or whatever combination of food, supplementation, and sunlight gets your blood level of 25-hydroxy vitamin D to to 50 ng/mL.)
  • Aspirin 81-325 mg/day
  • Vitamin C 500 mg/day
  • Elemental zinc 10-50 mg/day
  • Melatonin 1.5-6 mg/day at night or bedtime

The doses vary, depending on body weight, age, tolerance to the drug. Generally, the higher doses are for younger and heavier folks. If one gets plentiful sunlight exposure, the oral vitamin D may not be needed.

Other strategies during disease surges (or always?):

  • Regular exercise
  • Lose excess weight, especially if obese (BMI over 30)
  • Maintain normal blood sugars (if diabetic, keep HgbA1c under 6.5%)
  • Avoid close, prolonged contact with coughing and sneezing people, especially in enclosed spaces
  • Frequent hand-washing if exposed to public doorknobs, elevator buttons, or other potentially contaminated surfaces, or if around sick (coughing and/or sneezing) people
  • Avoid sick people who are coughing and sneezing
  • Eat healthful food

Did you notice I haven’t mentioned masks? I’m not a big believer. Do I wear an N-95 mask when I’m seeing a COVID-19 patient at the hospital? You bet. And the mask was fit-tested. Is that testing available to the general public? Not that I’m aware.

Do I have great data to support all these strategies? No, but some. Are they recommended by the CDC or NIH (Nat’l Institutes of Health)? I don’t know or care. I’ve lost faith in them. I’m afraid they’ve been bought and paid for by Big Pharma (and others?).

I don’t know about your personal health and medical history. I’m not your doctor. If you’re considering any of these recommendations, consult your personal physician before implementation.

The patient is wise to look away. If you watch the needle go in, it’ll hurt more.

I was motivated to write this post by the failures and risks of the rushed vaccines. Vaccination might be helpful if you are sickly, over 65, or have underlying conditions such as diabetes, active cancer, a poor immune system, obesity (especially BMI over 35), or some other co-morbidities. I see both very healthy, vigorous 65-year-olds, and sickly 65-year-olds. Which one are you? If you’re over 80, you may have nothing to lose by vaccinating. Average U.S. life expectancy is 79 years, less for men, longer for women.

Steve Parker, M.D.

PS: Updated Dec 28, 2021

Ultra-Processed Foods Linked to Higher Coronary Artery Disease Risk

Ultra-processed versus processed?

What are ultra-processed foods? I’m not paying $35 for the scientific article to find out. If you can grab the definition from your copy, please share in the Comments section. The 2020 profit from my publishing company was only $937.08, so I’m watching my expenses.

Here’s the free abstract:

ABSTRACT

Background

Higher ultra-processed food intake has been linked with several cardiometabolic and cardiovascular diseases. However, prospective evidence from US populations remains scarce.

Objectives

To test the hypothesis that higher intake of ultra-processed foods is associated with higher risk of coronary artery disease.

Methods

A total of 13,548 adults aged 45–65 y from the Atherosclerosis Risk in Communities study were included in the analytic sample. Dietary intake data were collected through a 66-item FFQ. Ultra-processed foods were defined using the NOVA classification, and the level of intake (servings/d) was calculated for each participant and divided into quartiles. We used Cox proportional hazards models and restricted cubic splines to assess the association between quartiles of ultra-processed food intake and incident coronary artery disease.

Results

There were 2006 incident coronary artery disease cases documented over a median follow-up of 27 y. Incidence rates were higher in the highest quartile of ultra-processed food intake (70.8 per 10,000 person-y; 95% CI: 65.1, 77.1) compared with the lowest quartile (59.3 per 10,000 person-y; 95% CI: 54.1, 65.0). Participants in the highest compared with lowest quartile of ultra-processed food intake had a 19% higher risk of coronary artery disease (HR: 1.19; 95% CI: 1.05, 1.35) after adjusting for sociodemographic factors and health behaviors. An approximately linear relation was observed between ultra-processed food intake and risk of coronary artery disease.Conclusions

Higher ultra-processed food intake was associated with a higher risk of coronary artery disease among middle-aged US adults. Further prospective studies are needed to confirm these findings and to investigate the mechanisms by which ultra-processed foods may affect health.

Article

I admit I must eat some ultra-processed foods, but I try to limit them.

Heart disease is the #1 killer in the developed world, even more lethal the COVID19! If you haven’t chosen your New Years’ weight-loss diet yet, consider one low in ultra-processed foods, like the paleo diet or Mediterranean diet.

This Shrimp Salad is minimally-processed

Steve Parker, M.D.

Rice: Great Source of Calories, But How Much Is Too Much?

Eliza Skoler addresses this issue in an interesting article at Diatribe:

Rice. Billions of people around the world eat it every single day, for multiple meals a day – and it’s a primary food for many populations, with research showing that it provides about 20% of the world’s calorie intake. From beans and rice to stir fry with rice, from sushi to risotto to sweet rice desserts, this simple ingredient is a staple across the globe and across cultures.

Unfortunately, rice presents a key challenge for people with diabetes: it’s a spiky carb. Spiky carbs are foods that cause glucose to quickly increase, and they can create unpredictable swings in glucose levels. If you or someone you know has diabetes, you may be wondering how to manage your glucose when faced with this dietary staple.

https://diatribe.org/rice-and-diabetes-how-great-risk

I find that many of my patients with diabetes have better glucose control if they eat fewer daily carb grams than mentioned in this article.

Steve Parker, M.D.

Parents: Don’t Let Them Vaccinate Your Children Against COVID-19

I say”them” because some government authorities around the world, e.g., Australia, will vaccinate against the wishes of parents. I worry that tyrants in California are about to do the same.

ketogenic diet, children
Healthy children have extremely low risk of death from COVID-19. Should we subject them to unknown risks of vaccines just to save elderly Boomer lives?

These are experimental vaccines without a long-term safety record. The short-term record in adults doesn’t look that great either.

Jonathan Howard at Science-Based Medicine figures that fewer than one in 100,000 healthy children who contract COVID-19 will die from it. Among the young decedents, at least three out of four have a predisposing condition such as obesity, asthma, a developmental disorder, a neurological condition, or cardiovascular disease. Additionally, Dr. Howard says three out of four deaths are in Hispanics, Blacks, or indigenous people (American Indian/Alaskan Native).

Dr. Howard admits that the risk of death from COVID-19 for children is very low. But since the risk is not zero, all children should be vaccinated.

Dr. Howard bases his recommendation for the Pfizer/BionNTech vaccine for children on very limited data. This is child abuse since we don’t have long-term vaccination safety data.

You know I’m not a pediatrician. Dr. Howard is a neurologist and psychiatrist. There may be a legitimate role of COVID-19 vaccination for sickly children. But there’s no way in hell I’d vaccinate my healthy children without long-term safety data.

For a healthy child, the potential risks of COVID-19 vaccination outweigh the potential benefits.

Question authority. Including me.

Steve Parker, M.D.

PS: Read William M Briggs: Kids Don’t Need to Be Vaccinated.

Eat Nuts and Seeds to Reduce Risk of Liver Disease

What kind of liver disease? NAFLD: non-alcoholic fatty liver disease.

Paleobetic diet
Macadamia nuts

See the Journal of Nutrition for details:

Conclusions

“Daily consumption for nuts and seeds was associated with a lower prevalence of NAFLD in non-Mediterranean, US adults, although the benefits seem to be greater in females across all categories of nut and seed consumption groups compared with nonconsumers. Both males and females presented with lower prevalence of NAFLD with intakes of 15–30 g/d.”

Stages of liver damage: Healthy, fatty liver, fibrosis, and cirrhosis

Nuts are paleo!

Steve Parker, M.D.