Dr Terry Wahls for several years has advocated a radical diet for multiple sclerosis patients. She has (or had) the disease herself, and achieved a dramatic improvement with a diet, as I recall, fairly compliant with generally accepted paleo principles. She certainly seems to be a true believer.
I have yet to run across a patient in person who has even heard of the Wahls protocol.
In the video linked above, Dr Wahls says she saw improvement after three months of her new way of eating, with continued improvement over the next 3–9 months or longer.
Dr Wahls and associates are putting it to the test.
BACKGROUND:Fatigue is one of the most disabling symptoms of multiple sclerosis (MS) and contributes to diminishing quality of life. Although currently available interventions have had limited success in relieving MS-related fatigue, clinically significant reductions in perceived fatigue severity have been reported in a multimodal intervention pilot study that included a Paleolithic diet in addition to stress reduction, exercise, and electrical muscle stimulation. An optimal dietary approach to reducing MS-related fatigue has not been identified. To establish the specific effects of diet on MS symptoms, this study focuses on diet only instead of the previously tested multimodal intervention by comparing the effectiveness of two dietary patterns for the treatment of MS-related fatigue. The purpose of this study is to determine the impact of a modified Paleolithic and low saturated fat diet on perceived fatigue (primary outcome), cognitive and motor symptoms, and quality of life in persons with relapsing-remitting multiple sclerosis (RRMS).