Dr. Richard Bernstein Not a Fan of Insulin Pumps

Click for details at DiabetesHealth. Dr. Bernstein is a type 1 diabetic and one of the first users of a home blood glucose monitor. He’s most famous for recommending very-low-carb eating for folks with diabetes, in his book Diabetes Solution. An excerpt from DiabetesHealth:

I spent a month in a major insulin pump center and saw several things. Many of the female patients seemed to have wings on their sides where the pump tubing was inserted and they got lipohypertrophy [overgrown fat tissue] from localized injections, but that was the least of it. None of them actually had remotely normal blood sugars.

Another Study Links Diabetes and Prediabetes With Alzheimer’s Dementia

…according to an article at MedPageToday. A cohort of patients with mild to moderate Alzheimer’s were found to have unexpectedly high rates of impaired glucose tolerance or outright type 2 diabetes. We don’t know for sure if impaired glucose metabolism is a cause of dementia, or if some other factor links the two conditions. Until we have that answer, if I had impaired glucose metabolism, I’d work to improve it with loss of excess weight, exercise, and low-carb eating.

Here’s another article I wrote wondering if diabetes causes dementia.

Recommended Periodic Evaluations and Treatment Goals for Diabetics

If you don't like your physician, find a new one

If you don’t like your physician, find a new one

So, you’ve got diabetes. I’m sorry. You’ve got a heck of a lot of medical information to master.

Unless you have a good diabetes specialist physician on your team, you may not be getting optimal care. Below are some guidelines you may find helpful. The goal is to prevent diabetes complications. Many primary care physicians will not be up-to-date on the guidelines. Don’t hesitate to discuss them with your doctor. Nobody, not even your doctor, cares as much about your health as you do.

Annual Tests

The American Diabetes Association (ADA) recommends the following items be done yearly (except as noted) in non-pregnant adults with diabetes. (Incidentally, I don’t necessarily agree with all ADA guidelines.) The complete ADA guidelines are available on the Internet.

  • Lipid profile (every two years if results are fine and stable)
  • Comprehensive foot exam
  • Screening test for distal symmetric polyneuropathy: pinprick, vibration, monofilament pressure sense
  • Serum creatinine and estimate of glomerular filtration rate (MDRD equation)
  • Test for albumin in the urine, such as measurement of albumin-to-creatinine ratio in a random spot urine specimen
  • Comprehensive eye exam by an ophthalmologist or optometrist (if exam is normal, every two or three years is acceptable)
  • Hemoglobin A1c at least twice a year, but every three months if therapy has changed or glucose control is not at goal
  • Flu shots

Other Vaccinations, Weight Loss, Diabetic Diet, Prediabetes, Alcohol, Exercise, Etc.

Additionally, the 2013 ADA guidelines recommend:

  • Pneumococcal vaccination. “A one time re-vaccination is recommended for individuals >64 years of age previously immunized when they were <65 years of age if the vaccine was administered >5 years ago.” Also repeat the vaccination after five years for patients with nephrotic syndrome, chronic kidney disease, other immunocompromised states (poor ability to fight infection), or transplantation.
  • Hepatitis B vaccination to unvaccinated adults who are 19 through 59 years of age.
  • Weight loss for all overweight diabetics. “For weight loss, either low-carbohydrate, low-fat calorie-restricted, or Mediterranean diets may be effective in the short-term (up to two years).” For those on low-carb diets, monitor lipids, kidney function, and protein consumption, and adjust diabetic drugs as needed. The optimal macronutrient composition of weight loss diets has not been established. (Macronutrients are carbohydrates, proteins, and fats.)
  • “The mix of carbohydrate, protein, and fat may be adjusted to meet the metabolic goals and individual preferences of the person with diabetes.” “It must be clearly recognized that regardless of the macronutrient mix, total caloric intake must be appropriate to weight management goal.”
  • “A variety of dietary meal patterns are likely effective in managing diabetes including Mediterranean-style, plant-based (vegan or vegetarian), low-fat and lower-carbohydrate eating patterns.”
  • “Monitoring carbohydrate, whether by carbohydrate counting, choices, or experience-based estimation, remains a key strategy in achieving glycemic control.”
  • Limit alcohol to one (women) or two (men) drinks a day.
  • Limit saturated fat to less than seven percent of calories.
  • During the initial diabetic exam, screen for peripheral arterial disease (poor circulation). Strongly consider calculation of the ankle-brachial index for those over 50 years of age; consider it for younger patients if they have risk factors for poor circulation.
  • Those at risk for diabetes, including prediabetics, should aim for moderate weight loss (about seven percent of body weight) if overweight. Either low-carbohydrate, low-fat calorie-restricted, or Mediterranean diets may be effective in the short-term (up to 2 years). Also important is exercise: at least 150 minutes per week of moderate-intensity aerobic activity. “Individuals at risk for type 2 diabetes should be encouraged to achieve the U.S. Department of Agriculture (USDA) recommendation for dietary fiber (14 g fiber/1,000 kcal) and foods containing whole grains (one-half of grain intake).” Limit intake of sugar-sweetened beverages.
  • “Adults with diabetes should be advised to perform at least 150 min/week of moderate-intensity aerobic physical activity (50–70% of maximum heart rate), spread over at least 3 days/week with no more than two consecutive days without exercise. In the absence of contraindications, adults with type 2 diabetes should be encouraged to perform resistance training at least twice per week.”
  • Screening for coronary artery disease before an exercise program is depends on the physician judgment on a case-by-case basis. Routine screening is not recommended.
Steve Parker MD, low-carb diet, diabetic diet

Olives, olive oil, and vinegar: classic Mediterranean foods

Clearly, some of my dietary recommendations conflict with ADA guidelines. The paleo diet isn’t even on their radar screen. The experts assembled by the ADA to compose guidelines were well-intentioned, intelligent, and hard-working. The guidelines are supported by 528 scientific journal references. I greatly appreciate the expert panel’s work. We’ve simply reached some different conclusions. By the same token, I’m sure the expert panel didn’t have unanimous agreement on all the final recommendations. I invite you to review the dietary guidelines yourself, discuss with your personal physician, then decide where you stand.

General Blood Glucose Treatment Goals

The ADA in 2013 suggests these therapeutic goals for non-pregnant adults:

  • Fasting blood glucoses: 70 to 130 mg/dl (3.9 to 7.2 mmol/l)
  • Peak glucoses one to two hours after start of meals: under 180 mg/dl (10 mmol/l)
  • Hemoglobin A1C: under 7%
  • Blood pressure: under 140/80 mmHg
  • LDL cholesterol: under 100 mg/dl (2.6 mmol/l). (In established cardiovascular disease: <70 mg/dl or 1.8 mmol/l may be a better goal.)
  • HDL cholesterol: over 40 mg/dl (1.0 mmol/l) for men and over 50 mg/dl (1.3 mmol/l) for women
  • Triglycerides: under 150 mg/dl (1.7 mmol/l)

The American Association of Clinical Endocrinologists (AACE) in 2011 proposed somewhat “tighter” blood sugar goals for non-pregnant adults:

  • Fasting blood glucoses: under 110 mg/dl (6.11 mmol/l)
  • Peak glucoses 2 hours after start of meals: under 140 mg/dl (7.78 mmol/l)
  • Hemoglobin A1C: 6.5% or less

The ADA reminds clinicians, and I’m sure the AACE guys agree, that diabetes control goals should be individualized, based on age and life expectancy of the patient, duration of diabetes, other diseases that are present, individual patient preferences, and whether the patient is able to easily recognize and deal with hypoglycemia. I agree completely.

Steve Parker, M.D.

Dr. Richard Bernstein on the Paleo Diet for Diabetes

DiabetesHealth has a brief article on Dr. Bernstein’s view of the Paleolithic diet. They quote him thusly:

There’s no way the ADA [American Diabetes Association] diet or any high-carbohydrate and low-fat diet will enable you to control blood sugars. It turns out that the kind of diet I recommend is essentially a Paleolithic diet, which is what humanity evolved on. Our ancestors did not have bread, wheat, sweet fruits, and all of the delicious things that we have today. These have been specially manufactured for us nowadays. For food, our ancestors had a paucity of roots, some leaves, and principally meat to eat. If they lived near the shore, they had fish.

Read the rest.

Dr. Deans on the Care and Feeding of Zoo Humans

When I explain to my patients why paleo-style eating may be the healthiest diet, I use a thought experiment. It goes like this. You find an injured or weak bird in your yard and you hope to nurse it back to health. First you need to identify the bird’s species since that will tell you what to offer as food. Most birds specialize in what they’re able to eat in order to survive and thrive. Some eat only seeds, leaves, or other plant matter. Others eat only specific insects, grubs, or worms. You get the idea. Get the food choice wrong, and you’ve got a dead bird on your hands.

Emily Deans gives a similar rationale for the paleo diet at her Psychology Today blog. She writes:

At the Cleveland Metroparks Zoo in 2005, a gorilla died of heart disease at the age of 21. Heart disease is the leading killer of captive gorillas, who also seem to be vulnerable to developing ulcerative colitis, and autoimmune disease of the gut. That led researchers to consider changing the gorilla diets, which at typical zoos had been filled with processed animal chows, meat, yogurt, milk, eggs, bread, and cereal grains along with large amounts of various fruits and vegetables. Free ranging wild gorillas, on the other hand, eat mostly immature leaves, stems, some bark, saplings, wild fruits, insects, and some small animals. The diet of the gorillas in the wild has an incredibly high fiber content, which is used as food by the may trillions of bacteria in the gorilla’s extremely long gut. The fiber is transformed into a short chain fatty acid called butyrate that is important for colonic health and may be the reason (along with the cereal grains and other unusual foods) the captive gorillas developed ulcerative colitis.

Read the rest.

 

Do Vegetables and Fruits Prevent Disease?

Switching to the paleo diet often leads to increased vegetable and fruit consumption

Switching to the paleo diet often leads to increased vegetable and fruit consumption

Potential answers are in the American Journal of Clinical Nutrition (2012).  I quote:

For hypertension, coronary heart disease, and stroke, there is convincing evidence that increasing the consumption of vegetables and fruit reduces the risk of disease. There is probable evidence that the risk of cancer in general is inversely associated with the consumption of vegetables and fruit. In addition, there is possible evidence that an increased consumption of vegetables and fruit may prevent body weight gain. As overweight is the most important risk factor for type 2 diabetes mellitus, an increased consumption of vegetables and fruit therefore might indirectly reduces the incidence of type 2 diabetes mellitus. Independent of overweight, there is probable evidence that there is no influence of increased consumption on the risk of type 2 diabetes mellitus. There is possible evidence that increasing the consumption of vegetables and fruit lowers the risk of certain eye diseases, dementia and the risk of osteoporosis. Likewise, current data on asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis indicate that an increase in vegetable and fruit consumption may contribute to the prevention of these diseases. For inflammatory bowel disease, glaucoma, and diabetic retinopathy, there was insufficient evidence regarding an association with the consumption of vegetables and fruit.

It bothers me that vegetables and fruits are lumped together: they’re not the same.

The paleo diet is unfairly characterized as meat-centric. It can certainly provide beaucoup vegetables and fruits. Diabetics should be careful which ones they choose, to avoid spikes in blood sugar.

Steve Parker, M.D.

Scientific Reviews Support the Paleo Prescription for Potassium and Sodium

A pinch of salt helps reduce bitterness in coffee

A pinch of salt helps reduce bitterness in coffee

Most of us have heard that reducing salt (sodium) intake is supposed to be good for us, although even that’s debatable. Fewer have heard that higher potassium may healthful. Those diet characteristics—low sodium and high potassium—are naturally incorporated into the Paleolithic diet (aka Stone Age, caveman, hunter-gatherer or paleo diet).

Read MedPageToday for details.

The association between sodium restriction and lower rates of cardiovascular disease and mortality is a confusing mess. My gut feeling is that strict sodium avoidance is important for only 20% of the population, at most.

But make no mistake: If I were on the cusp of drug therapy for high blood pressure, I’d cut my sodium to 3 grams a day, lose excess weight, increase my potassium consumption, and get regular exercise, all in an effort to avoid drugs. (If my blood pressure was 170/103 or higher, I’d go on drugs, make all those lifestyle changes, then try to reduce my drugs later.)

From MedPageToday:

However, the assertion that reduced salt intake will have beneficial effects on disease outcomes contradicts the results of a 2011 meta-analysis, which failed to show significant relationships between reduced salt intake and mortality or cardiovascular outcomes.

HIIT IT!

A treadmill is one of many ways to do high-intensity interval training.  Tabata's classic study used a stationary bicycle.

A treadmill is one of many ways to do high-intensity interval training. Tabata’s classic study used a stationary bicycle.

I found a free article by Martin Gibala,Ph.D., a major researcher into high-intensity interval training (HIIT).  He prefers to abbreviate it as HIT.

I don’t like to exercise, so I’ve been incorporating HIIT  into my workouts for over a year.  It’s helped me maintain my level of fitness to that required of U.S. Army soldiers, without being a exercise fanatic.

So what’s HIIT?  Gibala’s definition:

High-intensity interval training is characterized by repeated sessions of relatively brief, intermittent exercise, often performed with an “all out” effort or at an intensity close to that which elicits peak oxygen uptake (i.e., ≥90% of VO2peak).

HIIT involves short sessions of very intense exercise two or three times per week, for as little as 15 minutes.  That’s total time, not 15 minutes per session!  Yet you see a significant fitness improvement.  Be aware: the brief exercise bouts should be exhausting.

The Gibala article has all the scientific journal references you’d want, plus a suggested HIIT program for an absolute beginner.

One final quote from Dr. Gibala:

It is unlikely that high-intensity interval training produces all of the benefits normally associated with traditional endurance training. The best approach to fitness is a varied strategy that incorporates strength, endurance and speed sessions as well as flexibility exercises and proper nutrition. But for people who are pressed for time, high-intensity intervals are an extremely efficient way to train. Even if you have the time, adding an interval session to your current program will likely provide new and different adaptations. The bottom line is that — provided you are able and willing (physically and mentally) to put up with the discomfort of high-intensity interval training — you can likely get away with a lower training volume and less total exercise time.

Read the rest.

Steve Parker, M.D.

PS:  Why won’t Gibala give some credit to Izumi Tabata who did a pioneering study on HIIT in 1996?

PPS:  Gibala narrated this stationary bike HIIT video.

h/t Tony Boutagy

QOTD: Victoria on Teenage Breasts

Teenage girls are being brought up to believe that their breasts are two pre-cancerous lesions… ticking time bombs.

Victoria at PrincipleIntoPractice

Maybe We Don’t Need as Much Calcium As We Think

I’ve worried about the relatively low calcium amounts provided by most paleo diets.  Maybe I shouldn’t. Fanatic Cook Bix has a new post about various calcium absorption mechanisms in our bodies. If intake is low, certain mechanisms kick in, allowing us to absorb more than is usual. I quote:

So, someone who is eating less than 400 mg – which is half the recommended amount (the DRIs are 800-1000 mg/day, some groups recommend up to 1300 mg) – may, all else being equal, end up with a similar calcium status as someone eating 1000 mg or more because an active transport mechanism kicks in at lower intakes. As well, more calcium may be absorbed from the colon.

Calcium is not unusual in this regard. Absorption of nutrients is often higher when intake is low, and vice versa. Zooming in on one nutrient, in this case calcium, and fretting over whether we’re “getting enough” has a downside if it leads to taking supplements. Many nutrients compete for intestinal absorption, e.g. zinc supplements have been shown to substantially reduce calcium absorption. And, it should be said, what the body doesn’t absorb goes out with the feces.

It may be better to focus on eating a variety of minimally processed foods than to focus on discrete nutrients, and let the body take care of itself.

Read the rest.

At any given time, I usually have at least one little old lady on my hospital service who has fallen and fractured her hip, wrist, pelvis, or humerus (arm bone that’s part of the shoulder). Nearly always she has the bone-thinning disease called osteoporosis, which may be related to calcium consumption. If we can prevent osteoporosis with diet and exercise, that’s much preferable to dealing with the fractures.